362992
EPOR (Erythropoietin Receptor, EPO-R)
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£479.00
- SKU:
- 362992
- Reinheit:
- Purified by Protein A and peptide affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Pro33-Leu210 of human EPOR, expressed in E. coli.
- Format:
- Supplied as a liquid in 0.01M PBS, pH7.4, 0.05% Proclin-300, 50% glycerol.
- Weitere Details:
- Erythropoietin receptor(EPOR) is a 66kD peptide and is a member of the cytokine receptor superfamily that contains aW-S-X-W-S motif and four cysteine residues in the extracellar domain. Erythropoietin (EPO) is the regulator of red blood cell formation. Its receptor (EPOR) is now found in many cells and tissues of the body. EpoR is also shown to occur in tumor cells and Epo enhances the proliferation of these cells through cell signaling. EPOR antagonist can reduce the growth of the tumor in vivo. EpoR is expressed in high or low affinity forms, but the high-affinity receptor is likely the more physiologically relevant class. A peak in EpoR expression occurs on erythroid progenitor cells at the CFU-E/proerythroblast stage, but subsequently decreases following maturation and differentation; EpoR cannot be detected on reticulocytes. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice