362918
ECRG4 (Esophageal Cancer Related Gene 4, C2orf40, Augurin)
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£517.00
- SKU:
- 362918
- Anwendung:
- WB
- Reinheit:
- Purified by Protein A and peptide affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Asn32-Tyr148 of human ECRG4, expressed in E. coli.
- Format:
- Supplied as a liquid in 0.01M PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
- Weitere Details:
- Yue et al. (2003) reported that they had cloned C2ORF40, which they called ECRG4, from normal human esophageal epithelium. The deduced ECRG4 protein shares 31% homology with mouse IgG V region.Yue et al. (2003) demonstrated that methylation of CpG sites in the ECRG4 promoter correlated with ECRG4 downregulation in 12 (80%) of 15 esophageal squamous cell carcinoma tissues. Normal esophageal epithelium and normal tissues adjacent to tumors showed high ECRG4 expression and lacked promoter methylation. SAGE and RT-PCR analysis showed an inverse relationship between ECRG4 expression level and hypermethylation.Yue et al. (2003) determined that the C2ORF40 gene contains 4 exons spanning about 13 kb. The 5-prime UTR contains multiple cis-acting elements and 16 CpG islands. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice