362461
CD320 (Cluster Of Differentiation 320, 8D6, 8D6A, CD320 Antigen, TCblR, FDC-signaling molecule 8D6, Transcobalamin receptor)
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£537.00
- SKU:
- 362461
- Reinheit:
- Purified by immunoaffinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to Pro36-Leu256 of rat CD320, expressed in E. coli.
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Weitere Details:
- Transcobalamin II (TCN2), a plasma protein secreted by endothelial cells, binds the cobalamin absorbed in the distal ileum and carries 10 to 30% of total circulating cobalamin. CD320 encodes a transcobalamin receptor that binds TCN2-cobalamin at the plasma membrane and internalizes the complex by endocytosis.Functional analysis by Li et al. (2000) indicated that expression of 8D6 enhanced B-cell proliferation and immunoglobulin secretion. Treatment of the FDC cell line and a lymphoma cell line coculture with anti-8D6 resulted in at least partial inhibition of lymphoma growth. Li et al. (2000) proposed that antagonists of the 8D6 signaling pathway may counter the growth of follicular lymphomas or other tumors that metastasize to lymphoid follicles. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:5000 Western Blot: 1:50-1:400 Immunocytochemistry: 1:50-1:500 Immunohistochemistry (frozen): 1:50-1:500 Immunohistochemistry (paraffin): 1:10-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice