CCbL1 (Cysteine Conjugate Beta Lyase, Cytoplasmic, KATI, GTK, Cysteine-S-conjugate beta-lyase, Glutamine-phenylpyruvate transaminase, Kyneurenine Aminotransferase, Kynurenine Oxoglutarate Transaminase)

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£626.00

SKU:: 362427
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: 0°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Recombinant protein corresponding to Met1-Leu422 of human CCbL1 expressed in E. coli.
Format:: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Weitere Details:: Cysteine conjugate beta-lyase metabolizes cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites that can produce nephrotoxicity and neurotoxicity in experimental animals and man. CCBL1 is a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene.Comparison of the deduced aa sequence with that of the rat enzyme indicated an 82% overall similarity, with 90% similarity around the pyridoxal phosphate-binding site. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:100-5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Versandbedingungen:: Blue Ice