AIP (Aryl Hydrocarbon Receptor Interacting Protein, ARA9, XAP2, AH receptor-interacting protein, HBV X-associated protein 2, Immunophilin homolog ARA9)

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£626.00

SKU:: 362068
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Recombinant protein corresponding to Ile63-Pro296 of human AIP, expressed in E. coli.
Format:: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Weitere Details:: Aryl hydrocarbon receptor interacting protein, may play a positive role in AHR-mediated signalling possibly by influencing its receptivity for ligand and/or its nuclear targeting. AIP is the cellular negative regulator of the HBV X protein. The aryl hydrocarbon receptor (AHR) is found in a multiprotein complex that includes the 90-kD heat shock protein (HSP90). The AHR is a ligand-activated transcription factor that is a member of the basic helix-loop-helix PAS superfamily. In response to ligand binding in the cytosol, the AHR-HSP90 complex translocates to the nucleus where the molecular chaperone HSP90 dissociates and the activated AHR heterodimerizes with ARNT. The resulting complex attains binding specificity for its cognate enhancer elements to regulate transcription of a variety of xenobiotic metabolizing enzymes. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:5000 Western Blot: 1:50-400 Immunohistochemistry (frozen): 1:50-500 Immunohistochemistry (paraffin): 1:10-100 Immunocytochemistry: 1:50-500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Versandbedingungen:: Blue Ice