Integrin alpha M (CD11b, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor, Complement receptor 3)

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£735.00

SKU:: 361660
Reinheit:: Purified by Protein A affinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Mouse
Immunogen:: Wild type (WT) recombinant CD11b.
Klon:: 107 (recomb)
Format:: Supplied as a liquid in PBS, pH 7.2, 0.02% Proclin-300.
Weitere Details:: Recombinant monoclonal antibody to Integrin alpha-M with variable regions (i.e. specificity) from the original hybridoma 107. Manufactured using a proprietary recombinant platform technology. Integrin alpha-M (ITAM, ITGAM, CD11b, MAC-1 alpha subunit, CR3 alpha chain) is the alpha subunit of ITAM/beta-2 complex (CD11b/CD18, Mac-1), a leukocyte adhesion heterodimeric glycoprotein. ITAM belongs to integrin alpha chain family and it is predominately presented in human myeloid cells, NK1 cells, monocytes, and granulocytes. ITAM/beta-2 complex is a receptor for fibrinogen (binding to P1 and P1 peptides of gamma chain), factor X, and ICAM1. ITAM/beta-2 is implicated in adhesive interactions of monocytes, macrophages, and granulocytes. It is also linked to mediation of complement-coated particle uptake. Applications: Suitable for use in ELISA, Flow Cytometry and Blocking Experiments. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Application Notes: Binds specifically to integrin alpha-M, a protein subunit of the alpha-M- beta-2 molecule, which is expressed on the surface of leukocytes. Integrin alpha-M is involved in the adhesive interaction between molecules of the innate immune system, and plays a role in the uptake of complement-coated particles. Has a blocking activity by binding to the metal-ion-dependent-adhesion site, favoring a low affinity conformation of the antigen. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Versandbedingungen:: Blue Ice