CD30 (CD30L Receptor, Cytokine Receptor CD30, Ki-1 Antigen, Lymphocyte Activation Antigen CD30, Tumor Necrosis Factor Receptor Superfamily Member 8, TNFRSF8)

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£840.00

SKU:: 361545
Reinheit:: Purified by Protein A affinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Mouse
Immunogen:: Human CD30.
Klon:: Ki-4 (recomb)
Format:: Supplied as a liquid in PBS, pH 7.2, 0.02% Proclin-300.
Weitere Details:: Recombinant monoclonal antibody to CD30 with variable regions (i.e. specificity) from scFv Ki-4. Manufactured using a proprietary recombinant platform technology. The antibody binds specifically to CD30, a cell membrane protein which belongs to the tumor necrosis factor receptor family. Incubation of CD30 positive L540 cells with Ki-4 completely inhibits release of soluble CD30. CD30 is expressed on activated lymphocytes, and binding by its ligands TRAF2 and TRAF5 results in the activation of NF-kappaB, thereby regulating gene expression. CD30 is also associated with Hodgkin Lymphoma, and its expression acts as a tumor marker. Targeting the CD30 antigen with specific monoclonal antibodies is a possible therapy for Hodgkin's lymphoma. Applications: Suitable for use in Immunofluorescence, Flow Cytometry, ELISA, Immunohistochemistry and Inhibition Studies. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Versandbedingungen:: Blue Ice