352609
TRIM21 (SSA, RO52, SSA1, RNF81, Ro/SSA, E3 ubiquitin-protein ligase TRIM21, 52kD Ro protein, SS-A)
Größe
£655.00
- SKU:
- 352609
- Reinheit:
- Purified by immunoaffinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Peptide corresponding to 16aa near the center of human TRIM21. Epitope: aa290-340. Species Sequence Homology: bovine; 73%, mouse and rat; 69%, rat, 69%.
- Format:
- Supplied as a liquid in PBS, 0.02% sodium azide.
- Weitere Details:
- TRIM21, a member of the tripartite motif (TRIM) family, is a part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. TRIM21 also acts as a cytosolic antibody receptor; detection of intracellular antibodies activate immune signaling by stimulating the transcription factor pathways of NF-kappaB, AP-1, IRF3, IRF5, and IRF7, resulting in the production of proinflammatory cytokines and the induction of an antiviral state. Applications: Suitable for use in Immunofluorescence, ELISA, Western Blot AND Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunofluorescence: 20ug/ml Western Blot: 0.5-1ug/ml Immunohistochemistry (Paraffin): 5ug/ml. Heat mediation with a citrate buffer, pH 6. Optimal dilutions to be determined by the researcher. Positive Control: HUman Lung Tissue Lysate Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice