MESDC2, Recombinant, Mouse, aa30-224, His-Tag (LDLR chaperone MESD, Mesd, mKIAA0081, Msd)

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£512.00

SKU:: 351366
Molekulargewicht:: 24.4
Reinheit:: ~90% (SDS-PAGE)
Lagerbedingungen:: -20°C/-70°C
Hersteller:: United States Biological
Format:: Supplied as a liquid in PBS, pH 7.4, 10% glycerol.
Weitere Details:: MESDC2 is also known as LDLR chaperone MESD. This protein is specialized chaperone for low- density lipoprotein receptor-related protein 5 and LRP6. MESDC2 binds to mature LRP6 on the cell surface and blocks the binding of Wnt antagonist Dickkopf-1 to LRP6. Furthermore, MESDC2 plays an essential role in NMJ formation by promoting Lrp4 maturation. Source: Recombinant protein corresponding to aa30-224 from mouse MESDC2, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~24.4kD (218aa) Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSADTPGEA TPPPRKKKDI RDYNDADMAR LLEQWEKDDD IEEGDLPEHK RPSAPIDFSK LDPGKPESIL KMTKKGKTLM MFVTVSGNPT EKETEEITSL WQGSLFNANY DVQRFIVGSD RAIFMLRDGS YAWEIKDFLV SQDRCAEVTL EGQMYPGKGG GSKEKNKTKP EKAKKKEGDP KPRASKEDNR AGSRREDL Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.