CRADD (Caspase and RIP Adapter with Death Domain, RAIDD, CRADD, Caspase and RIP Adapter with Death Domain, Caspase and RIP Adapter with Death Domain CASP2 and RIPK1 Domain Containing adaptor with Death Domain, Death adaptor molecule RAIDD, Death Domain Containing Protein CRADD, RIP associated ICH1/CED3 homologous Protein with Death Domain, RIP associated Protein with a Death Domain)

Größe

£438.00

SKU:: 349812
Reinheit:: Purified by Protein A affinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Mouse
Immunogen:: Recombinant protein corresponding to aa1-199 from human CRADD expressed in E. coli.
Klon:: 16C33
Format:: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 10% glycerol.
Weitere Details:: CRADD, also referred as RAIDD, is an adaptor protein that could interact with both caspase 2 and RIP that can promote apoptosis once activated. RAIDD (RIP-associated ICH-1/Ced-3 homologous protein with a death domain) has been identified as a RIP binding protein that also associates with members of the caspase family, providing a link between activation of the TNF-Rs and the triggering of the cysteine protease cascade. The amino-terminal domain of RAIDD shares significant homology with the prodomain of ICH-1 and mediates the binding of RAIDD to this cysteine protease. Applications: Suitable for use in ELISA, Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Hybridoma: FO myeloma cells with spleen cells from Balb/c mice. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.