337634
TP53INP2 (Tumor Protein p53-inducible Nuclear Protein 2, Diabetes and Obesity-regulated Gene, p53-inducible Protein U, PIG-U, TP53INP2)
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£364.00
- SKU:
- 337634
- Reinheit:
- Purified by immunoaffinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to the N-terminal region of human TP53INP2.
- Format:
- Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
- Weitere Details:
- TP53INP2 (tumor protein p53 inducible nuclear protein 2), also known as DOR or PINH, is a 220aa nuclear protein that is expressed in developing murine brain and spinal cord, as well as in the sensory and motor neuron tracts of the peripheral nervous system. A novel protein involved in the autophagy of mammalian cells, TP53INP2 translocates from the nucleus to the autophagosome structures after activation of autophagy by rapamycin or starvation. Necessary for autophagosome development and considered a scaffold protein, TP53INP2 recruits LC3 and/or LC3-related proteins, such as GABARAP and GABARAP-like2, to the autophagosome membrane by interacting with the transmembrane protein TMEM49. The gene encoding TP53INP2 is located on human chromosome 20, which is comprised of approximately 2% of the human genome and contains nearly 63 million bases that encode over 600 genes. Applications: Suitable for use in Immunofluorescence, ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunofluorescence: 1:200-1:1000 ELISA: 1:10,000 Immunohistochemistry: 1:100-1:300 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice