DOK2 (Docking Protein 2, Downstream Of Tyrosine Kinase 2, p56(Dok-2))

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£544.00

SKU:: 327263
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Peptide corresponding to the sequence around aa297-301 (G-E-Y-A-V) derived from Human p56Dok-2.
Format:: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 0.02% sodium azide, 50% glycerol.
Weitere Details:: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation Feng Cong, et,al. (1999) Mol. Cell. Biol; 19: 8314 - 8325. Serge Lemay, et,al. (2000) Mol. Cell. Biol; 20: 2743 - 2754. Ute Schaeper, et,al.(2000) J. Cell Biol; 149: 1419. Miyuki Honma, et,al. (2006) Genes Cells; 11: 143 - 151. Applications: Suitable for use in Immunofluorescence and Western Blot. Other applications not tested. Recommended Dilution: Immunofluorescence: 1:100-1:200 Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.