ID4 (DNA-Binding Protein Inhibitor ID-4, Class B basic Helix-Loop-Helix Protein 27, bHLHb27, Inhibitor of DNA Binding 4, ID4, BHLHB27)

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£460.00

SKU:: 319888
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to human ID4.
Format:: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 40% glycerol.
Weitere Details:: DNA-binding protein inhibitor ID-4 is a protein that in humans is encoded by the ID4 gene. Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative (antimorph) HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins. Applications: Suitable for use in ELISA, Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:1000-1:5000 Immunohistochemistry: 1:20-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.