Girdin, phosphorylated (Ser1417) (Girdin, Akt Phosphorylation Enhancer, APE, Coiled-coil Domain-Containing Protein 88A, G alpha-interActing Vesicle-Associated Protein, GIV, Girders of Actin Filament, Hook-Related Protein 1, HkRP1, CCDC88A)

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£518.00

SKU:: 317183
Anwendung:: IHC-Fr
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Peptide corresponding to the sequence around phosphorylation site of Serine 417(L-E-M(p)-A-Q) derived from Human Girdin .
Format:: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 0.02% sodium azide, 50% glycerol.
Weitere Details:: girdin IS a ubiquitously expressed actin binding protein that plays an important role in the formation of stress fibers and lamellipodia. Subsequent to phosphorylation by Akt, Girdin accumulates at the leading edge of migrating cells and appears to be crucial for the integrity of the actin cytoskeleton and for cell migration. Enomoto A., Dev. Cell 9:389-402(2005). Simpson F., Traffic 6:442-458(2005). Hillier L.W., Nature 434:724-731(2005). Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: 1:50-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.