CERS6

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£460.00

SKU:: 310550
Reinheit:: Purified by immunoaffinity chromatography
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to human CERS6
Format:: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 40% glycerol
Weitere Details:: The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they all are involved in sphingolipid synthesis. LASS6 is a widely expressed 384aa endoplasmic reticulum, multi-pass membrane protein. On the luminal side of the endoplasmic reticulum membrane, the N-terminal asparagine residue is glycosylated. In cells deficient for CLN9, LASS6 corrects growth and apoptosis, and increases the levels of short ceramide species, such as C14:0- and C16:0-ceramides. Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilutions: ELISA: 1:2000-1:5000 Immunohistochemistry (Paraffin): 1:50-1:200 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.