MEK4, CT (C Jun N Terminal Kinase Kinase 1, C-JUN N-terminal Kinase Kinase 1, Dual Specificity Mitogen Activated Protein Kinase Kinase 4, Dual Specificity Mitogen-activated Protein Kinase Kinase 4, JNK Activated Kinase 1, JNK Activating Kinase 1, JNK-activating Kinase 1, JNKK, JNKK1, MAP Kinase Kinase 4, Map2k4, MAPK ERK Kinase 4, MAPK/ERK Kinase 4, MAPKK 4, MAPKK4, MEK 4, MEK4, Mitogen Activated Protein Kinase Kinase 4, MKK 4, MKK4, PRKMK4, SAPK ERK Kinase 1, SAPK/ERK Kinase 1, SEK1, SERK1)

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£620.00

SKU:: 303448
Anwendung:: WB
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to aa360-378, ELLKHPFILMYEERAVEVA, from human MEK4 at C-terminus, different from the related mouse and rat sequences by 1aa.
Format:: Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% thimerosal, 0.05% sodium azide. Reconstitute with 200ul sterile dH2O.
Weitere Details:: Dual specificity mitogen-activated protein kinase kinase 4(MAP2K4), also called SEK1 or JNKK1, is an enzyme that in humans is encoded by the MAP2K4 gene. It is mapped to 17p12. This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK1. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. MAP2K4 was a specific activator of JNK1, JNK2, and p38, and it has been shown to interact with FLNC, MAPK8, MAPK8IP3 and AKT1. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.1-0.5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Versandbedingungen:: Blue Ice