Uhrf2 (E3 Ubiquitin-Protein Ligase UHRF2, 632-, NIRF, Np95-like ring Finger Protein, Nuclear Protein 97, Nuclear Zinc Finger Protein Np97, Ubiquitin-like PHD and RING Finger Domain-Containing Protein 2, Ubiquitin-like-Containing PHD and RING Finger Domains Protein 2, Uhrf2, Nirf)

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£696.00

SKU:: 302828
Anwendung:: WB
Reinheit:: Purified by Protein A affinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: KLH conjugated synthetic peptide corresponding to aa472-505 at the Central region of Mouse Uhrf2.
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Weitere Details:: E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131 (By similarity). E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.