CASC5 (Protein CASC5, ALL1-fused gene from Chromosome 15q14 Protein, AF15q14, Bub-linking Kinetochore Protein, Blinkin, Cancer Susceptibility Candidate gene 5 Protein, Cancer/Testis antigen 29, CT29, Kinetochore-null Protein 1, Protein D40/AF15q14, CASC5, KIAA1570, KNL1)

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£696.00

SKU:: 302320
Anwendung:: WB
Reinheit:: Purified by Protein A affinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: KLH conjugated synthetic peptide corresponding to aa2324-2357 from human CASC5.
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Weitere Details:: Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.