302126
Pro-SAAS, aa243-252, Mouse
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£320.00
- SKU:
- 302126
- Molekulargewicht:
- 1023.11
- Reinheit:
- ~95% (HPLC)
- Lagerbedingungen:
- 4°C
- Hersteller:
- United States Biological
- Format:
- Supplied as a white powder.
- Weitere Details:
- ProSAAS is a newly discovered protein with a neuroendocrine distribution generally similar to that of prohormone convertase 1 (PC1), a peptide processing endopeptidase. ProSAAS mRNA is broadly distributed among neurons in brain and other neuroendocrine tissues (pituitary, adrenal, pancreas). Overexpression of ProSAAS in the AtT-20 cells substantially reduces the rate of processing of POMC(endogenous prohormone proopiomelanocortin) [1]. In wild type mouse brain and pituitary, the majority of ProSAAS is processed into smaller peptides including Little SAAS, PEN and big LEN.[2] A few obesity related propeptides have been processed by PC1 and obesity has been observed to be associated with mutations in the human PC1 gene[3].Does proSAAS- derived peptides play a role in the development of obesity? Source: aa243-252, Mouse Molecular Weight: ~1023.11 Sequence: Leu-Glu-Asn-Pro-Ser-Pro-Gln-Ala-Pro-Ala Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Versandbedingungen:
- Blue Ice