PARK2 (Juvenile Parkinson Disease Autosomal Recessive 2, Parkinson Disease Autosomal Recessive 2, PARK 2, PARK-2, Parkin)

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£581.00

SKU:: 301444
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Residues aa62-80, DQQSIVHIVQRPWRKGQEM, of 52kD human Parkin.
Format:: Supplied as a liquid in PBS, 0.02% sodium azide.
Weitere Details:: Mutations in the gene, Parkin (PARK2), appear to be responsible for the pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role in the ubiquitin-mediated proteolytic pathway by removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of Parkin. Applications: Suitable for use in Immunoprecipitation and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:250-1:1000 Immunoprecipitation: 1:250-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.