299549
Transforming Growth Factor beta Receptor I (TGFBR1, TGF Beta R1, Transforming Growth Factor Beta)
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£512.00
- SKU:
- 299549
- Anwendung:
- IHC-Fr
- Reinheit:
- Supernatant.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Prokaryotic recombinant protein corresponding to the external domain of human Transforming Growth Factor beta Receptor I.
- Klon:
- 8A11
- Format:
- Supplied as a liquid in 15mM sodium azide.
- Weitere Details:
- Transforming growth factor beta (TGFB) inhibits cell proliferation and stimulates cell differentiation. This is achieved through a receptor complex of types I and II TGFB receptors. The type II receptor is a transmembrane serine/threonine kinase which is able to bind TGFB and transactivate the type I receptor. TGFB receptors are found in all myometrial tissues and, in the kidney, they are found exclusively in renal tubular cells. In normal gastric mucosa, type I and II receptors are demonstrated in fundic glands, but not on surface mucous cells and in normal small bowel and colon, TGFB receptors are expressed in the epithelial cells of the upper crypts. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry(Paraffin): 1:25-1:50 Trypsin digestion of paraffin sections may enhance staining in some cases. 60 minutes primary antibody incubation at 25° C Standard ABC technique. Immunohistochemistry(Frozen): 1:25-1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice