S-Adenosyl-L-methionine Disulfate Tosylate (doMet SAM Disulfate p-toluenesulfonate, SAMe)

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£225.00

SKU:: 295234
Molekulargewicht:: 766.8
Reinheit:: ≥95%
Lagerbedingungen:: 4°C
Hersteller:: United States Biological
CAS Number:: 97540-22-2
Format:: White to off-white crystalline powder
Weitere Details:: A methyl donor and a cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. SAM is anti-apoptotic in normal hepatocytes and normal colon epithelial cells but pro-apoptotic in liver human hepatocellular carcinoma (HCC), HepG2 cells and colon cancer cells. Synonyms: Ademetionine Disulfate Tosylate; 4-Methylbenzenesulfonate (salt) Sulfate (salt) (1:1:1:1) (9CI); FO 1561; S-Adenosyl-L-methionine Disulfate Tosylate; 5'-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxyadenosine Sulfate 4-Methylbenzenesulfonate Sulfate; (3S)-5'-[(3-Amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine Sulfate 4-Methylbenzenesulfonate; 5'-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxyadenosine Sulfate 4-methylbenzenesulfonate Sulfate CAS No: 97540-22-2 Free Base: 28594-13-0 Molecular Formula: C₂₂H₃₄N₆O₁₆S₄ Molecular Weight: 766.8 Appearance: White to off-white crystalline powder Purity: ≥95% Melting Point: >122°C (dec.) (lit) Heavy Metals: ≤0.001% Water (Karl Fischer): ≤2% Storage and Stability: Store at 4ºC. Stable for 6 months after receipt.