295176
9-(b-D-Arabinofuranosyl)guanine
Größe
£288.00
- SKU:
- 295176
- Molekulargewicht:
- 283.24
- Reinheit:
- ≥98%
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- CAS Number:
- 38819-10-2
- Format:
- White to off-white powder
- Weitere Details:
- Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine (Item No. 20248).1,2 Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into the DNA.3,1 Ara-G inhibits DNA replication by 92% after 30 minutes when used at a concentration of 50 µM in CEM cells, which are used as a model for human T lymphoblasts.1 It also halts the cell cycle at the sub-G1 phase and induces apoptosis in CEM cells.3 Syngeneic bone marrow containing 6C3HED tumor cells treated with ara-G (100 mM) ex vivo prior to transplantation increases survival of lethally irradiated mice and induces reconstitution of lymphoid, myeloid, and erythroid cell linages.4 Synonyms: 2-Amino-9-β-D-arabinofuranosyl-1,9-dihydro-6H-purin-6-one; 2-Amino-6-hydroxy-9-(β-D-arabinofuranosyl)purine; 9-β-D-Arabinofuranosylguanine; Arabinoguanosine; Araguanosine; Guanine arabinoside; NSC 76352; ara-Guanosine CAS No: 38819-10-2 Molecular Formula: C10H13N5O5 Molecular Weight: 283.24 Appearance: White to off-white powder Purity: ≥98% Melting Point: >245°C (dec.) Solubility: Aqueous Base (Slightly, Sonicated), DMSO (Slightly) Storage and Stability: Store at -20°C under inert atmosphere. Hygroscopic. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Versandbedingungen:
- Ambient