257185
TNFR Type II (CD120b, TNF R Type II/p75, TNFRII, p75, TNFR80, TNFRSF1B, TNFR Superfamily, 75kD) (Low Endotoxin, Azide Free)
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£576.00
- SKU:
- 257185
- Reinheit:
- Purified by affinity chromatography. Endotoxin: <0.1EU/ug
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Hamster
- Immunogen:
- E. coli expressed mouse Type II TNFR
- Klon:
- TR75-32.4
- Format:
- Supplied as a liquid in PBS, pH 7.2. No preservative added.
- Weitere Details:
- CD120b is a 75kD type I transmembrane protein, also known as Tumor Necrosis Factor Receptor Type II (TNFRII) or p75. It is expressed on a variety of cells at low levels; the expression is upregulated upon activation. This receptor binds both TNF-a and LT-a (also known as TNF-b). In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-a or LT-a trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state. The antibody has been shown to block ligand-induced receptor signaling. Applications: Suitable for use in Immunofluorescence, Flow Cytometry, ELISA, Immunoprecipitation, Functional assays, Receptor blocking. Other applications not tested. Recommended Dilution: Flow Cytometry: ≤0.5ug/10e6 cells in 100ul volume ELISA Detection: 0.125-0.5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice