PDE5A (CGB PDE, CGBPDE, cGMP Binding cGMP specific 3' 5' cyclic nucleotide phosphodiesterase, cGMP Binding cGMP specific 35 cyclic nucleotide phosphodiesterase, cGMP Binding cGMP specificphosphodiesterase, cGMP Binding/cGMP specific phosphodiesterase, cGMP specific 3'5' cyclicphosphodiesterase, CN5A, CN5N, PDE 5, PDE 5A, PDE5, PDE5A1, Phosphodiesterase 5A, Phosphodiesterase 5A cGMP specific) (Not for Export EU)

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£731.00

SKU:: 254231
Reinheit:: Serum
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Designed from the C-terminal region common to the 5A isoform
Format:: Supplied as a liquid.
Weitere Details:: Phosphodiesterase 5A, a cGMP-specific phosphodiesterase, has been implicated in primary pulmonary hypertension, cardiac failure and erectile dysfunction. PDE5A also may function in the regulation of coronary blood flow. PDE5A is the predominant enzyme responsible for cGMP hydrolysis in trabecular smooth muscle. PDE5A activitity is inhibited by sildenafil (Viagra) and zaprinast. At least three alternatively spliced transcripts have been reported. Applications: Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:20,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.