226802
BimS/EL/L (BCL2L11, Bcl-2-like Protein 11, Bcl2-interacting Mediator of Cell Death) [KO Validated]
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£469.00
- SKU:
- 226802
- Reinheit:
- Purified by Protein G affinity chromatography.
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Host:
- Rat
- Immunogen:
- Synthetic peptide corresponding to aa20-40 of mouse BimL.
- Klon:
- 10B12
- Format:
- Supplied as a liquid in PBS, 0.02% sodium azide, 25% glycerol.
- Weitere Details:
- Bim belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the Bcl-2 protein family (BCL2, BCL2L1/BCL-X(L) and MCL1) and to act as an apoptotic activator, inducing apoptosis and anoikis. Several variants have been identified. The isoforms vary in cytotoxicity with isoform BimS being the most potent and isoform BimEL being the least potent. Applications: Suitable for use in Flow Cytometry, ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-5ug/ml Immunoprecipitation: 1-2ug/ml Optimal dilutions to be determined by the researcher. Endotoxin: <0.1EU/ug purified protein (LAL test; Lonza). Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Versandbedingungen:
- Blue Ice