TrkB Antagonist, ANA-12 (N-(2-((2-oxoazepan-3-yl)carbamoyl)phenyl)benzo[b]thiophene-2-carboxamide)

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£497.00

SKU:: 217848
Reinheit:: ≥98% (HPLC)
Lagerbedingungen:: 4°C
Hersteller:: United States Biological
CAS Number:: 219766-25-3
Format:: Supplied as a white solid.
Weitere Details:: A cell-permeable thiophene carboxymide derived compound that acts as a direct and selective antagonist of TrkB receptor. Binds to the high affinity site on the extracellular domain of TrkB in a dose-dependent manner (Kd = 10nM) exhibiting much reduced binding to the low affinity site (Kd =12uM) indicating that it does not compete with BDNF for the same binding site. Does not affect TrkA or TrkC receptors. Shown to permeate the blood-brain barrier, however, its antagonistic effects are not uniform throughout the brain. Does not affect the survivability of neurons. Reduces anxiety and depression related behavior in mice. CAS Number: 219766-25-3 Molecular Formula: C₂₂H₂₁N₃O₃S Solubility: DMSO Primary Target: TrkB Primary Target Ki: 10nM Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.