STAT3 Inhibitor XI, STX-0119 (N-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-2-phenylquinoline-4-carboxamide)

Größe

£524.00

SKU:: 217810
Molekulargewicht:: 382.4
Reinheit:: ≥90% (HPLC)
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Format:: Supplied as a grayish to off-white solid.
Weitere Details:: A cell-permeable oxadiazolyl-quinolinecarboxamide that is shown to selectively suppress STAT3, but not STAT1, STAT5a, or STAT5b, DNA binding activity and prevent IL-6-stimulated STAT3 dimerization in HEK293 cells (by 99% at 100uM), as well as inhibit the expression of STAT3 target genes both in cultures in vitro (effective conc. 50uM) and in SCC3-derived tumors in mice in vivo (160mg/kg/day; p.o.). Formula: C22H14N4O3 Molecular Weight: 382.4 Solubility: DMSO Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.