217795
SKP2 E3 Ligase Inhibitor II, SMIP004 (CRL1SKP2 Inhibitor II, p21/Cip1/CKI/Waf1 Activator II, N-(4-Butyl-2-methylphenyl)acetamide, p27/Kip1 Activator II, S-phase Kinase-associated Protein 2 Inhibitor II, SCFSKP2 Inhibitor II, Small Molecule Inhibitor of p27 Depletion 004)
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£557.00
- SKU:
- 217795
- Molekulargewicht:
- 205.3
- Reinheit:
- ≥99% (HPLC)
- Lagerbedingungen:
- 4°C
- Hersteller:
- United States Biological
- CAS Number:
- 143360-00-3
- Format:
- Supplied as a white solid.
- Weitere Details:
- A cell-permeable phenylacetamide compound that is shown to upregulate p21Cip1/Waf1 and/or p27Kip1 in prostate cancer LNCaP, PC3, DU145, but not HeLa, cultures (40uM for 24h) with a concomitant downregulation of the F-box E3 ubiquitin ligase Skp2 and a delayed G1-to-S cell cycle transition, displaying no apparent effect toward cell cycle progression or p21 and p27 levels in non-cancer human fibroblast IMR90. SMIP004 antiproliferative activity against LNCaP, PC3, DU145 soft agar colony formation is mainly cytostatic with cytotoxicity observed only in LNCaP cultures at high concentrations (IC50 = 40uM in 72h), but not PC3 or DU145 even at concentrations as high as 80uM and for up to 96h. Synonyms: p27/Kip1 Activator II, S-phase Kinase-associated Protein 2 Inhibitor II, SCFSKP2 Inhibitor II, Small Molecule Inhibitor of p27 Depletion 004, CRL1SKP2 Inhibitor II, p21/Cip1/CKI/Waf1 Activator II, N-(4-Butyl-2-methylphenyl)acetamide CAS No: 143360-00-3 Molecular Formula: C₁₃H₁₉NO Solubility: DMSO Molar Mass: 205.30 Purity: ≥99% (HPLC) Form: Supplied as a white solid. Storage and Stability: May be stored at 4°C for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Versandbedingungen:
- Blue Ice