SKP2 E3 Ligase Inhibitor I, C1 (p21/Cip1/Waf1 Activator I; p27/Kip1 Activator I, S-phase Kinase-associated Protein 2 Inhibitor I; SCFSKP2 Inhibitor I, CRL1SKP2 Inhibitor I, (Z)-2-(4-Bromo-2-((4-oxo-3-(pyridin-3-ylmethyl)-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic Acid)

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£557.00

SKU:: 217794
Molekulargewicht:: 465.3
Reinheit:: ≥99% (HPLC)
Lagerbedingungen:: 4°C
Hersteller:: United States Biological
CAS Number:: 432001-69-9
Format:: Supplied as an orange brown powder.
Weitere Details:: A cell-permeable rhodanine compound that upregulates cellular p21Cip1/Waf1 and p27Kip1 protein levels (10uM for 16h in 501 Mel cultures) by preventing Skp2-Cks1-mediated substrate recruitment without affecting the F-box E3 ubiquitin ligase Skp2 interaction with Cks1 or the SCF (Skp1-cullin1-F-box) complex. Shown to inhibit the proliferation of human breast cancer MCF-7 and melanoma 501 Mel cells (IC50 = 8 and 30uM, respectively; 16h incubation). Unlike SMIP004, C1 does not affect cellular Cyclin E/CDK2 kinase activity or Skp2 level. Synonyms: p21/Cip1/Waf1 Activator I; p27/Kip1 Activator I, S-phase Kinase-associated Protein 2 Inhibitor I; SCFSKP2 Inhibitor I, CRL1SKP2 Inhibitor I, (Z)-2-(4-Bromo-2-((4-oxo-3-(pyridin-3-ylmethyl)-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid CAS No: 432001-69-9 Molecular Formula: C₁₈H₁₃BrN₂O₄S₂ Solubility: DMSO Primary Target: disrupts p27-Skp2 interaction Molar Mass: 465.3 Purity: ≥99% (HPLC) Form: Supplied as an orange brown powder. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4ºC for 6 months after receipt. Light sensitive.