SHIP2 Inhibitor II, CPDA

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£466.00

SKU:: 217789
Reinheit:: ≥98% (HPLC)
Lagerbedingungen:: 4°C
Hersteller:: United States Biological
Format:: Supplied as a white solid.
Weitere Details:: A cell-permeable aminopyridine acetamide based compound that acts as an inhibitor of SH2 domain-containing inositol 5’-phosphatase 2 (SHIP2) that can overcome insulin resistance in 3T3-L1 adipocytes. Enhances insulin-stimulated Akt phosphorylation (Thr308) in TNFa-treated 3T3-L1 adipocytes (~10uM) and in primary cultured neurons from rat cerebral cortex. Improves glucose tolerance in db/db mice (~300mg/kg b.i.d) without affecting their fasting glucose levels. Also reduces the expression levels of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase. Molecular Formula: C₂₀H₁₅ClF₂N₂O₂ Primary Target: SHIP2 Solubility: DMSO Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.