217786
gamma-Secretase Inhibitor XXV, FT-9 (2-[3-(3,5-dichlorophenoxy)phenyl]propanoic Acid)
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£386.00
- SKU:
- 217786
- Molekulargewicht:
- 311.2
- Reinheit:
- ≥97% (HPLC)
- Lagerbedingungen:
- 4°C
- Hersteller:
- United States Biological
- Format:
- Supplied as an off-white powder.
- Weitere Details:
- FT-9, a cell-permeable NSAID-like compound, is a partially selective gamma-Secretase Inhibitor in both microsomes and whole cells. Displays dose-dependent inhibition of the gamma-secretase cleavage of beta-Amyloid Precursor Protein (APP) and APLP2 with IC50 values against APP ICD (intracellular domain) and APLP2 ICD of ˜260uM, but there is a less potent effect on gamma-secretase processing of APLP1. The concentration of FT-9 required to cause a 2-fold increase in APP CTFs, 3.4 +/- 0.4uM, is significantly lower than that for APLP1 (25.7 +/- 8.9uM) (P = 0.001). For comparison, the concentration of another gamma-Secretase inhibitor compound E needed for a 2-fold increase in the magnitude of the CTF band signal is not significantly different, being 0.27nM for APP versus 0.24nM for APLP1. This is the first example that a GSI can preferentially target APP processing while sparing other gamma-substrates. Synonyms: 2-[3-(3,5-dichlorophenoxy)phenyl]propanoic acid Molecular Formula: C₁₅H₁₂Cl₂O₃ Solubility: DMSO Molar Mass: 311.2 Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
- Versandbedingungen:
- Blue Ice