RGS Proteins Inhibitor II, CCG-50014 (4-(4-Fluorobenzyl)-2-p-tolyl-1,2,4-thiadiazolidine-3,5-dione)

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£358.00

SKU:: 217741
Molekulargewicht:: 316.4
Reinheit:: ≥98% (HPLC)
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Format:: Supplied as a white solid.
Weitere Details:: A cell-permeable thiadiazolidinedione compound that acts as a direct, potent, selective and cysteine-reactive irreversible inhibitor of RGS4 over other RGS proteins (IC50=0.03, 0.12, 3.5, 11, >200 and >200uM against RGS4, RGS19, RGS16, RGS8, RGS7 and RGS4Cys- using FCPIA assay, respectively). Shown to block RGS4-Ga0 interaction and repress Ga0-dependent membrane localization of RGS4 in HEK-293T cells with no effect on the intrinsic rate of GTP hydrolysis by Ga0. Suggested to interact with Cys107-RGS8 allosteric regulatory site and display minimal affinity towards papain (IC50>100uM). Synonyms: 4-(4-Fluorobenzyl)-2-p-tolyl-1,2,4-thiadiazolidine-3,5-dione Formula: C₁₆H₁₃FN₂O₂S Molecular Weight: 316.4 Solubility: DMSO (50mg/ml) Appearance: Supplied as a white solid. Purity: ≥98% (HPLC) Storage and Stability: Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.