RAD51 Inhibitor, B02 ((E)-3-Benzyl-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one)

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£479.00

SKU:: 217733
Molekulargewicht:: 339.4
Reinheit:: ~98% (HPLC)
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
CAS Number:: 1290541-46-6
Format:: Supplied as a light yellow powder.
Weitere Details:: A cell-permeable pyridinylvinyl-quinazolinone compound that is shown to specifically inhibit human RAD51 (IC50=27.4uM). Does not affect RecA even at much higher concentration (~250uM). Directly interacts with RAD51 (=5.6uM), and disrupts its binding to DNA and nucleoprotein filament formation. Blocks double-strand break-induced homologous recombination and enhances sensitivity of cells to Cisplatin and Mitomycin C. Diminishes co-aggregate formation between RAD51-ssDNA filament and dsDNA. RAD51-Stimulatory Compound-1, RS-1 is also available. CAS No: 1290541-46-6 Formula: C22H17N3O Molecular Weight: 339.4 Solubility: DMSO (50mg/ml) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.