Prodigiosin, Serratia marcescens (NSC 47147, Casein Kinase I Inhibitor IV, 2-Methyl-3-pentyl-6-methoxyprodigiosene)

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£372.00

SKU:: 217703
Molekulargewicht:: 323.4
Reinheit:: ≥95% (HPLC)
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
CAS Number:: 82-89-3
Format:: Supplied as a dark red solid.
Weitere Details:: A cell-permeable tripyrrole alkaloid compound that displays immunosuppressive and anti-tumor properties irrespective of p53 status and multidrug resistance. Shown to selectively upregulate p21WAF/CIP1 and NAG-1 (nonsteroidal anti-inflammatory drug-activated gene 1) and downregulate survivin expression levels, induce mitochondria-mediated apoptosis and cell cycle arrest in tumor cells. Prevents FADD phosphorylation (IC50=2.0uM in A549-FKR cells) through inhibition of FADD-kinase CK1a (IC50 ~6.0uM in SW620-BGCR cells) and augments cisplatin -induced apoptosis. Blocks NF-kB activation by decreasing plkBa (by 63% at 3uM) and lkBa levels in A549 cells, and shrinks tumor growth in A549-FKR tumor xenograft mouse model (3mg/kg, i.p., o.d.). CAS Number: 82-89-3 Formula: C20H25N3O Molecular Weight: 323.4 Solubility: DMSO, DMF, EtOH, MeOH Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.