PPAR-beta/delta Inverse Agonist (Methyl 3-(N-(4-(hexylamino)-2-methoxyphenyl)sulfamoyl)thiophene-2-carboxylate, ST247)

Größe

£415.00

SKU:: 217691
Molekulargewicht:: 426.6
Reinheit:: ≥98% (HPLC)
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Format:: Supplied as an off-white solid.
Weitere Details:: A cell-permeable, diaryl sulfonamide inverse agonist that demonstrates selectivity for the ligand-binding domain of the PPAR beta/delta receptor (IC50=93nM). Enhances the interaction of the PPARb/d ligand-binding domain with the co-repressor, SMRT-ID2 (EC50=10nM). Down-regulates the peroxisome proliferator response elements (PPREs)-driven target gene, ANGPTL4. Inhibits PPARb/d- specific agonist-induced transcriptional activity in human myofibroblasts and mouse thioglycollate-elicited peritoneal macrophages. Formula: C₁₉H₂₆N₂O₅S₂ Molecular Weight: 426.6 Solubility: DMSO Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.