nNOS - PSD-95 Interaction Inhibitor, ZL006 (5-(3,5-dichloro-2-hydroxybenzylamino)-2-hydroxybenzoic Acid)

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£358.00

SKU:: 217595
Molekulargewicht:: 328.2
Reinheit:: ≥98% (HPLC)
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Format:: Supplied as an off-white solid.
Weitere Details:: A cell-permeable and blood-brain barrier-permeant aminosalicylic acid compound that selectively disrupts nNOS and PSD-95 interaction uponnMDAR activation both in primary murine cortical neurons (0.8- and 2.8-fold increase from basal level with or without 30min 10uM ZL006 pretreatment) in vitro and in mice (0.4- and 1.9-fold increase from basal level with or without inhibitor pretreatment 15min before ischemia; 1.5mg/kg i.v.) in vivo without affecting nNOS activity or non-nNOS-mediated nMDAR EPSCs (excitatory postsynaptic currents). Effectively reduce ischemia-caused brain tissue damage in both mice and rats when applied 1h after blood reperfusion following ishemia (60% and 50% reduction of infarction, respectively; 1.5mg/kg i.v.). Formula: C₁₄H₁₁Cl₂NO₄ Molecular Weight: 328.2 Solubility: DMSO (50mg/ml) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.