MIF Antagonist V, p425 (Sodium 6,6’-(1E,1’E)-(3,3’-dimethoxybiphenyl-4,4’-diyl)bis(diazene-2,1-diyl)bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate))

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£288.00

SKU:: 217550
Molekulargewicht:: 992.8
Reinheit:: ~95% (HPLC)
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
CAS Number:: 2610-05-1
Format:: Supplied as a blue solid.
Weitere Details:: A symmetrical bis-(amino, hydroxynaphthalenedisulfonate) compound that antagonizes macrophage migration inhibitory factor against receptor binding (IC50=810nM against hMIF and CD74 interaction) and is more potent than ISO-1 in suppressing MIF-induced cytokines and MMP-3 productions in human fibroblasts cultures (IC50= <0.7uM vs >5uM). Unlike MIF Antagonists I-IV, p425 targets an area at the interface of two MIF trimers, distal to the active site. CAS Number: 2610-05-1 Formula: C34H24N6Na4O16S4 Molecular Weight: 992.8 Solubility: H2O (25mg/ml) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.