217463
iPSC Induction Enhancer II, OAC1 N-(1H-Pyrrolo[2,3-c]pyridin-5-yl)benzamide, Induced Pluripotent Stem Cells Induction Enhancer II, Oct4-Activating Compound 1)
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£442.00
- SKU:
- 217463
- Molekulargewicht:
- 237.3
- Reinheit:
- ≥99% (HPLC)
- Lagerbedingungen:
- 4°C
- Hersteller:
- United States Biological
- CAS Number:
- 300586-90-7
- Format:
- Supplied as an off-white solid.
- Weitere Details:
- A cell-permeable pyrrolopyridinyl-benzamide compound that is reported to enhance the efficiency of 4F/4TF-induced iPSC generation from MEFs cultured in either feeder cell-containing ESC media or in feeder-/serum-free iSF1 media (1uM OAC1 treatment starts 48h after viral transduction). OCA1 is shown to increase cellular Oct4, Nanog, Sox2, and Tet1 mRNA levels via a yet unidentified mechanism, although OAC1 is reported not affect Oct4 promoter methylation, cellular Wnt signaling, or p53 and p21 mRNA levels. Six other iPSC reprogramming improving reagents, AM580, AzaC, BIX-01294, Tranylcypromine, VPA, and Vitamin C, in comparison, do not exhibit Oct4 and Nanog promoters enhancing activity, while BIO is demonstrated to be 3.8- and 6-fold less potent than OAC1, respectively, in inducing Oct4 and Nanog transcription. Synonyms: Induced Pluripotent Stem Cells Induction Enhancer II, Oct4-Activating Compound 1, N-(1H-Pyrrolo[2,3-c]pyridin-5-yl)benzamide CAS No: 300586-90-7 Molecular Formula: C₁₄H₁₁N₃O Molecular Weight: 237.3 Solubility: DMSO Molar Mass: 237.3 Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
- Versandbedingungen:
- Blue Ice