217334
eEF2K Inhibitor, A-484954 (7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, Eukaryotic Elongation Factor-2 Kinase Inhibitor, A-484954)
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£453.00
- SKU:
- 217334
- Molekulargewicht:
- 289.3
- Reinheit:
- ≥98% (HPLC)
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- CAS Number:
- 142557-61-7
- Format:
- Supplied as an off-white powder.
- Weitere Details:
- A cell-permeable pyrido-pyrimidinedione derivative that acts as a highly potent and selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50=280nM). Exhibits very little activity against a broad panel of serine/threonine and protein tyrosine kinases. Inhibits eEF2 phosphorylation in multiple cell lines tested without affecting the net eEF2 levels. At concentration where it inhibits eEF2K activity, it has no effect on the proliferation of cancer cell lines. CAS No.: 142557-61-7 Synonyms: 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, Eukaryotic elongation factor-2 kinase inhibitor, A-484954 Molecular Formula: C₁₃H₁₅N₅O₃ Molecular Weight: 289.3 Solubility: DMSO (2.5mg/ml, clear, colorless solution) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Versandbedingungen:
- Blue Ice