Dihydroorotate Dehydrogenase Inhibitor, Brequinar (6-fluoro-2-(2’-fluoro-1,1’-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic Acid Sodium Salt, NSC 368390, DuP 785)

Größe

£390.00

SKU:: 217314
Reinheit:: ≥98% (HPLC)
Lagerbedingungen:: 4°C
Hersteller:: United States Biological
CAS Number:: 96201-88-6
Format:: Supplied as an off-white solid.
Weitere Details:: A quinolinecarboxylic acid derivative with immunosuppressive and anti-neoplastic properties. Inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50 = 12nM). Does not affect DHODH in non-mammalian species. Also reported to inhibit glycosylation of adhesion molecules. Potentiates the sensitivity of U1690 small cell lung cancer cells to TRAIL-induced apoptosis and synergistically enhances the anti-tumor effects of doxorubicin ( ~100uM). Synonyms: 6-fluoro-2-(2ʹ-fluoro-1,1ʹ-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic acid sodium salt, NSC 368390, DuP 785 CAS Number: 96201-88-6 Molecular Formula: C₂₃H₁₄F₂NNaO₂ Primary Target: DHODH Primary Target IC50: 12nM Solubility: DMSO Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.