Cyclopamine-KAAD (3-Keto-N-aminoethyl-aminocaproyldihydrocinnamoyl cyclopamine, Shh Signaling Antagonist II)

Größe

£499.00

SKU:: 217304
Molekulargewicht:: 698
Reinheit:: ≥70% HPLC (sum of two isomers)
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
CAS Number:: 306387-90-6
Format:: Supplied as a pale yellow solid.
Weitere Details:: A potent, cell-permeable analog of Cyclopamine that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20nM in Shh-LIGHT2 assay; 50nM in p2Ptch-/-cells; 500nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both the ShhNp-induced pathway activity and SmoA1-induced reporter activity. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. Synonyms: 3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine, KAAD-Cyclopamine, Shh Signaling Antagonist II CAS No: 306387-90-6 Molecular Formula: C₄₄H₆₃N₃O₄ Primary Target: Hh signaling in Shh-light2 assay Primary Target IC50: 20nM Secondary Target: in P2Ptch-/-cells (IC50 = 50nM) Solubility: DMSO, EtOH, or MeOH Molecular Weight: 698 Storage and Stability: Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.