217261
Cdc25 Inhibitor IV, NSC 95397 (2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedione, PTP Inhibitor XXIX)
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£435.00
- SKU:
- 217261
- Molekulargewicht:
- 310.4
- Reinheit:
- ≥95% (HPLC)
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- CAS Number:
- 93718-83-3
- Format:
- Supplied as an orange solid.
- Weitere Details:
- A cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (Ki=32nM, 96nM, and 40nM for Cdc25A, -B, and -C, respectively) and blocks G2M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC50=1.8uM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments. Synonyms: (2,3-bis-[2-hydroxyethylsulfanyl]-[1,4]naphthoquinone), PTP Inhibitor XXIX CAS Number: 93718-83-3 Molecular Formula: C₁₄H₁₄O₄S₂ Molecular Weight: 310.4 Solubility: DMSO (100mg/ml, clear red solution) Storage and Stability: Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Versandbedingungen:
- Blue Ice