Bicuculline (GABAA Receptor Antagonist, (+)-Bicuculline)

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£433.00

SKU:: 217220
Molekulargewicht:: 367.35
Reinheit:: ≥98% (HPLC)
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
CAS Number:: 485-49-4
Format:: Pale yellow solid
Weitere Details:: A potent allosteric antagonist of vertebrate GABAA receptors. Blocks GABAA-induced chloride currents in cultured neurons (IC50 = 740nM). Shown to increase blood pressure in spontaneously hypertensive rats and cause convulsion in experimental animals. Also, increases the amplitude of spontaneous colonic contractions. CAS No: 485-49-4 Molecular Formula: C₂₀H₁₇NO₆ Molecular Weight: 367.35 Appearance: Pale yellow solid Purity: ≥99% (HPLC) Melting Point: 193-197°C (lit) Primary Target: GABA-A Primary Target IC50: 740Nm Solubility: DMSO Elemental Analysis: C: 64-66%; H: 4-5.5%; N: 3-5% Water by CHN (mol): ≤1.0mol Optical Rotation: +130º-145º Storage and Stability: Powder is stable for 6 months after receipt at 4°C. Hygroscopic. Under inert atmosphere.