AMPK Signaling Activator XIII, ZLN005 (2-(4-tert-Butylphenyl)-1H-benzo[d]imidazole, 2-(4-(2-Methyl-2-propanyl)phenyl)-1H-benzimidazole, Luciferase Inhibitor IV)

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£486.00

SKU:: 217177
Reinheit:: ≥99% (HPLC)
Lagerbedingungen:: 4°C
Hersteller:: United States Biological
CAS Number:: 4529-96-8
Format:: Supplied as a pinkish-white powder.
Weitere Details:: A cell-permeable benzimidazole that, in addition to its inhibitory potency against luciferase activity (IC50 <10nM), also activates AMPK signaling by increasing cellular ADP/ATP ratio via mitochondria respiration upcoupling, effectively activating AMPK & PGC-1alpha in muscle, but not liver, cell types both in cultures (5-20uM in rat L6 myotubes) in vitro and in db/db mice (15mg/kg/day via p.o.) in vivo. Reported to improve glucose and insulin tolerance of db/db mice without any apparent effects on body weight or food intake. Synonyms: 2-(4-tert-Butylphenyl)-1H-benzo[d]imidazole, 2-(4-(2-Methyl-2-propanyl)phenyl)-1H-benzimidazole, Luciferase Inhibitor IV CAS Number: 4529-96-8 Molecular Formula: C₁₇H₁₈N₂ Solubility: DMSO Primary Target: Increases cellular ADP/ATP ratio via mitochondria respiration uncoupling Secondary Target: Luciferase activity inhibitor Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.