Metastin (Kiss-1, G-Protein-Coupled Receptor 54, GPR54)

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£704.00

SKU:: 216819
Anwendung:: IHC-Fr
Reinheit:: Purified by Protein A affinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Metastin (1-52) / KiSS-1 (68-119).
Klon:: 14L723
Format:: Supplied as a lyophilized powder in PBS. Reconstitute with 100ul sterile PBS.
Weitere Details:: KiSS-1 gene encodes metastin, also known as kisspeptin or KiSS-1 peptide, which binds to a G protein-coupled receptor GPR54. KiSS-1 is dominantly expressed in brain (e.g. anteroventral periventricular nucleus, AVPV arcuate nucleus, ARC), placenta, and pancreas, etc. Metastin plays an important role in regulating the GnRH secretion in brain and MMP-9 expression in placenta, which is associated with development of puberty and sex maturation (e.g. Idiopathic hypogonadotropic hypogonadism, IHH) as well as placentation (e.g. pre-eclampsia), respectively. Metastin was originally discovered as a tumor metastasis suppressor (e.g. melanoma, breast cancer). Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:2000-1:8000 Immunohistochemistry(Paraffin): 1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Versandbedingungen:: Blue Ice