207349
POP1, Recombinant, Human, aa2-89, GST-Tag (Pyrin Domain-containing Protein 1, PAAD-only Protein 1, Pyrin-only Protein 1, ASC2, ASCI, PYDC1, PYC1)
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£338.00
- SKU:
- 207349
- Molekulargewicht:
- 38
- Reinheit:
- ≥95% (SDS-PAGE)
- Lagerbedingungen:
- -20°C
- Hersteller:
- United States Biological
- Format:
- Supplied as a lyophilized powder in PBS. Reconstitute with 100ul sterile dH2O.
- Weitere Details:
- The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family (NLRs), including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA). Pyrin domain-containing protein 1 (POP1) interacts with the protein Asc (Pycard) and modulates the interaction of Asc to NLR proteins. Recombinant protein corresponding to aa2-89 from human POP1, fused to a GST-tag at N-terminal, expressed in E. coli. Molecular Weight: ~38kD Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Versandbedingungen:
- Blue Ice