207170

FasL, Soluble, Recombinant, Human, aa139-281 (Apoptosis Antigen Ligand, APT1LG1, APTL, CD95 Ligand, CD95L, CD95-L, FAS Antigen Ligand, Fas Ligand, CD178, FASLG, Tumor Necrosis Factor Ligand Superfamily Member 6, TNFSF6)

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£439.00

SKU:: 207170
Molekulargewicht:: 50
Reinheit:: ≥95% (SDS-PAGE). Endotoxin: <0.01EU/ug (LAL)
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Format:: Supplied as a lyophilized powder in PBS. Reconstitute with 100ul sterile dH2O.
Weitere Details:: Fc (human):FasL, Soluble (human) is a high activity construct in which two trimeric FasL are artificially linked via the Fc binding domain of human IgG1. This construct very effectively simulates the natural membrane-assisted aggregation of FasL in vivo. FasL is a cytokine that binds to TNFRSF6/Fas, a receptor that transduces the apoptotic signal into cells. It is involved in cytotoxic T cell mediated apoptosis and in T cell development. Source: Recombinant protein corresponding to aa139-281 from human FasL, fused at the N-terminal to the Fc portion of human IgG1, expressed in HEK 293 cells. Molecular Weight: ~50kD (SDS-PAGE) Biological Activity: Induces apoptosis of human Jurkat T cells at a concentration of <0.2ng/ml. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.