207102

CD137: (Human):Fc (Human), Recombinant, aa19-184 (Tumor Necrosis Factor Receptor Superfamily Member 9, TNFRSF9, 4-1BB, 4-1BB Ligand Receptor T Cell, Antigen 4-1BB Homolog, T Cell Antigen ILA, CD137 Antigen, CDw137, ILA, MGC2172)

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£576.00

SKU:: 207102
Reinheit:: ≥98% (SDS-PAGE)
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Format:: Supplied as a lyophilized powder in PBS. Reconstitute with 100ul sterile ddH2O. Add 1X PBS to the desired protein concentration.
Weitere Details:: Human CD137 (4-1BB) is a costimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. The glycoprotein 4-1BB is expressed mainly on activated CD4+ and CD8+ T cells and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor receptor-associated factors (TRAF), the adaptor protein and mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T cell activation and growth as well as monocyte proliferation and B cell survival, and plays a important role in the amplification of T cell-mediated immune responses. In contrast, it can also enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, the 4-1BB/4-1BBL costimulatory pathway has been shown to augment secondary CTL responses to several viruses and increase antitumor immunity. 4-1BB is therefore a promising candidate for immunotherapy of human cancer. Source: Recombinant protein corresponding to aa19-184 from human CD137, fused to the N-terminus of the Fc region of human IgG1, expressed in CHO cells. Biological Activity: Measured by its binding ability in a functional ELISA. Endotoxin: <0.06EU/ug protein (LAL test; Lonza) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Versandbedingungen:: Blue Ice