SYVN1 (HRD1, KIAA1810, Synoviolin, Synovial Apoptosis Inhibitor 1, DER3)

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£709.00

SKU:: 171303
Anwendung:: IHC-Fr
Reinheit:: Purified by immunoaffinity chromatography.
Lagerbedingungen:: -20°C
Hersteller:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to 18aa from the internal region of human SYVN1/HRD1.
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Weitere Details:: HRD1, a Ubiquitin-protein ligase (E3), is required for the degradation and ubiquitination of several endoplasmic reticulum-associated degradation (ERAD) substrates and physically associates with relevant ubiquitin-conjugating enzymes (E2s). Human HRD1 is localized to the ER and ubiquitinates its substrates. HRD1 has been suggested to be up-regulated to protect against ER stress-induced apoptosis by degrading unfolded proteins accumulated in the ER. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 5-10ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.